Buy Kratom Resin
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Kratom Resin has become wildly
popular and continues to grow in popularity every day, despite the
newer and more potent extracts that are available.
So, we offer our favorite Kratom Extraction Recipe for
Kratom tea or Kratom Resin*
1. Grind 28 gm of leaf to a powder and put into a pot filled with 1
liter of water.
2. Gently boil, stirring often.
3. When about ½ liter is left, strain the leaves out, and place the
liquid aside.
4. Add a fresh 1 liter of water, add the leaves back, and gently
boil again.
5. When ½ liter is left, strain the leaves out and place the other
liquid with this liquid.
6. Discard the leaves/leaf powder.
7. Combine the 2 volumes of water/extract/liquid and gently boil
down.
To make tea:
Boil the liquid down to about 100ml and cool. Traditionally, it was
drank as a single serving (very strong), or as 2-4 separate servings
for milder effects.
To make tarry resin extract:
Reduce down to a tarry mixture, mix with powdered Chai tea mix and
fresh, crushed ginger (or whatever was desired) and then chill. Use
all at once for very strong effects, or split into 2-4 separate
servings for milder effects.
To make as a smoking admixture:
Sometimes the water/extract mixture was reduced to a resin, dried as
completely as possible, mixed with finely powdered leaf, and used
for burning, but reports are only somewhat reliable.
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* We offer this only as an educational reference; we do not advise,
endorse, or recommend doing anything mentioned in this text. The
product that is attached to this sheet is also not for ingestion in
any way, whether intentional or accidental.
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Over 25 alkaloids have been isolated from kratom. The most abundant
alkaloids consist of three indoles and two oxindoles which can be
extracted fromthe leaves in water and made into a crude resin. The
three indoles are mitragynine, paynanthine, and speciogynine - the
first two of which appear to be unique to this species. The two
oxindoles are mitraphylline and speciofoline. Other alkaloids
present include other indoles, and oxindoles such as ajmalicine,
corynanthedine, mitraversine, rhychophylline, and stipulatine.
Mitragynine is the dominant alkaloid in the plant. It was first
isolated in 1907 by D. Hooper, a process repeated in 1921 by E.
Field who gave the alkaloid its name. Its structure was first fully
determined in 1964 by D. Zacharias, R. Rosenstein and E. Jeffrey. It
is structurally related to both the yohimbe alkaloids and voacangine.
It is more distantly related to other tryptamine-based psychedelic
drugs such as psilocybin or LSD. Chemically, mitragynine is
9-methoxy-corynantheidine. It has the molecular formula C23H30N2O4
and a molecular weight of 398.5. Physically the freebase is a white,
amorphous powder with a melting point of 102-106 degrees and a
boiling point of 230-240 degrees. It is soluble in alcohol,
chloroform and acetic acid. The hydrochloride salt has a melting
point of 243 degrees.
The alkaloid content of the leaves of Mitragyna speciosa is about
0.5%, about half of which is mitragynine. An average leaf weighs
about 1.7 grams fresh or 0.43 grams dried. Twenty leaves contain
approximately 17mg of mitragynine. All leaves appear to contain
mitragynine, speciogynine, paynanthine, and small quantities of
speciociliatine. Oxindole alkaloids usually occur only in small or
trace ammounts.
Alkaloid content varies from place to place and at different times.
Within each location, there is a quantitative variation in alkaloid
content from month to month. While indole content seems to be fairly
stable, oxindole content shows tremendous variation.
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Kratom is traditionally only used in Thailand, although some use in
Malaysia has been reported. Besides kratom (or krathom), it also
goes by the names ithang, kakuam, and in southern regions, thom. Use
dates far enough back that its beginning can't be determined. In
addition to being used as a chew or herbal resin in its own right,
it is often used as a substitute for opium when opium is
unavailable, or to moderate opium addiction. A small minority of
users use kratom to prolong sexual intercourse.
Users distinguish different types of kratom, two main kinds being
distinguished by the color of veins in the leaf - red or
green/white. The green-veined variety is supposed to have a stronger
effect. One study which surveyed Thai kratom users found that most
users preferred a mixture of both, followed by red-veined alone and
then white-veined alone. Growers in Australia report that both red
and white veining occurs at different times in different plants
which were all cloned from the same mother plant. They have not yet
undertaken comparisons between the two.
Nearly all kratom use is by chewing fresh leaves. Other ways it is
taken include grinding up and eating fresh, dried, or reconstituted
dried leaves. Some villagers use the leaves in cooking. When
preparing fresh leaf, the vein is extracted and sometimes salt is
added to try and prevent constipation. Consumption of the leaf is
usually followed by drinking something hot, such as warm water or
coffee. Leaves can also be smoked, made into a tea, or a crude resin
extraction can be made. This resin extract is made by preparing a
water extract of the leaves, boiling it down, and then shaping it
into small balls which are rolled in a material such as flour, then
stored until use. This is apparently a quite popular method of
consumption.
Users of kratom tend to be peasants, laborers, and farmers who use
the plant to overcome the burdens of their hard work and meager
existences. Female users are apparently quite rare. Age of usage
onset seems to be higher than for other drugs. Some studies have
found no addiction problems in villagers using kratom, while others
apparently have. It seems likely that if used in doses high enough
for mu receptor crossover (discussed below), addiction is a strong
possibility. Heavy users may chew kratom between 3 and 10 times a
day. While new users may only need a few leaves to obtain the
desired effects, some users find with time they need to increase
doses to 10-30 leaves or even more per day.
In some parts of the country, it was said that parents would choose
to give their daughters in marriage to men who used kratom rather
than men who used marijuana. The belief is that kratom users are
hard working, while marijuana users are lazy. This belief is also
maintained by many of the users themselves, who report beginning use
because of a desire to work more efficiently, and who say using the
drug gives them a strong desire to do work.
The Thai government passed the Kratom Act 2486 which went into
effect on August 3, 1943. This law makes planting the tree illegal
and requires existing trees to be cut down. This law was not found
effective, since the tree is indigenous to the country. Today,
kratom is classed in the same enforcement group as cocaine and
heroin by Thai law, and has the same penalties. One ounce of extract
is punishable by death. As with prohibition laws elsewhere in the
world, this has succeeded only at increasing black market prices. A
related species, Mitragyna javanica, is often used as a substitute
to get around the law, but it is not considered as effective. The
dominant alkaloid in this species is mitrajavine, which has not yet
been pharmacologically tested.
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While the main alkaloids in kratom are structurally related to
psychedelics, there appears to be no psychedelic activity. The
dominant effects seem to be similar to opiate drugs, and include
analgesia and cough suppression. These effects are roughly
comparable in strength to codeine. Mitragynine suppresses opiate
withdrawal, but its effects are not reversed by the opiate
antagonist nalorphine. These opiate-like effects appear to be
mediated mostly by delta and mu opioid receptors. In lower dosages,
mitragynine exhibits a yohimbine-like binding to alpha-adrenergic
receptors, as well as some binding to the delta opioid receptors. As
doses increase, binding to delta receptors increases, and in yet
higher doses, crossover to mu receptors occurs. Interestingly, mu
crossover is increased by the presence of opiate drugs. While delta
receptor selective opiate drugs have little abuse potential, it
seems that they could be used as a primer which would allow
mitragynine to more effectively bind to the mu receptor, which
mediates the euphoric high produced by narcotics such as morphine.
Other effects of mitragynine are a reduction in smooth muscle tone,
local anesthesia, and central nervous system depression. Acute side
effects include dry mouth, increased urination, loss of appetite,
and constipation coupled with small, blackish stools. Unlike
opiates, mitragynine does not appear to cause nausea or vomiting.
Heavy use can result in a prolonged sleep.
Side effects from long term use include anorexia and weight loss,
insomnia, and a darkening of the skin, particularly on the cheeks,
giving an appearance similar to a hepatic face. Among addicts, 30%
report limited sexual desire and the need to use a combination of
kratom and alcohol to become sexually stimulated. One study found 5
people who had psychotic conditions which may or may not have been
revealed by very heavy kratom use. As discussed earlier, addiction
seems to be a possibility if high doses are used. Some withdrawal
symptoms reported by addicts include hostility, aggression, wet
nose, inability to work, flow of tears, muscle and bone aches, and
jerky limb movement.
While one study of Thai users reported that it is sedative in low
doses changing over to stimulation in higher doses, this seems to be
incorrect. Most other sources say that it is a stimulant in lower
doses, becoming sedative in higher doses, which is consistent with
mitragynine's receptor binding profile. Effects come on within five
to ten minutes after use, and last for several hours. The feeling
has been described as happy, strong, and active, with a strong
desire to do work. The mind is described as calm. The Swiss
biologist Claude Rifat experimented with a low dose of three smoked
leaves and reported the effects reminded him somewhat of SSRIs, in
that it blocked motivation, induced indifference, made doing
everything boring, and brought on a strong laziness. It seems likely
that these two almost opposite results may be influenced by cultural
expectations.
Inspired by traditional use, H. Ridley reported In 1897 that the
leaves of Mitragyna speciosa were a cure for opium addiction. In
more recent times, mitragynine has been used in New Zealand for
methadone addiction detox. Kratom was smoked whenever the patient
experienced withdrawal symptoms, over a 6 week treatment period.
Patients reported a visualization effect taking place at night in
the form of vivid hypnagogic dreams. While working on plans for
ibogaine experiments in the USA, Cures Not Wars activist Dana Beal
suggested that mitragynine could be used as an active placebo for
comparison in the study. Acting Deputy Director of the NIDA Charles
Grudzinskas rejected the proposal, however, saying that even less
was known about mitragynine than ibogaine.
Although chemically similar, ibogaine and mitragynine work by
different pathways, and have different applications in treatment of
narcotic addiction. While ibogaine is intended as a one time
treatment to cure addiction, mitragynine used to gradual wean the
user off narcotics. The fact that mitragynine's mu crossover is
increased by the presence of opiate drugs may be exploitable in the
treatment of narcotics addiction, because it directs binding to
where it is needed, automatically regulating the attachment ratio
and modulating it towards the delta receptors over a short time.
Within a few days, the addict would stop use of the narcotic they
are addicted to, and the cravings and withdrawal will be moderated
by the binding of mitragynine to the delta receptors. Mitragynine
could also perhaps be used as a maintenance drug for addicts not
wishing to quit but trying to moderate an out of hand addiction.
In 1999, Pennapa Sapcharoen, director of the National Institute of
Thai Traditional Medicine in Bangkok said that kratom could be
prescribed both to opiate addicts and to patients suffering from
depression, but stressed that further research is needed.
Chulalongkorn University chemists have isolated mitragynine which
researchers can obtain for study.
In conclusion, there seems to be much more research done into this
plant and its active constituents. Although kratom has been used
since time immemorial by Thai natives, Western science hasn't paid
it that much attention. What research does exist contains some
apparent conflicts. Knowledge even of the plant's existence outside
of Thailand has been limited to ethnobotanists and a handful of
pharmacology researchers. Availability of live plants and dried
leaves has been practically non-existent until very recently.
There is much to learn. - Murple
† The statements contained herein have not been evaluated by the
Food and Drug Administration. The information contained in this
website is intended for education, entertainment and
information purposes only. This information is not intended to be
used to diagnose, prescribe or replace proper medical care. The
plant described herein is not intended to treat, cure, diagnose,
mitigate or prevent any disease. Please refer to our Conditions of
Use for using this plant database file and web site.
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